dbCAC, a manually curated database, features in comprehensive annotations of genes and drugs related with cancer-associated cachexia (CAC) in human cancers. Currently, dbCAC covers 293 CAC genes (252 protein-encoding genes and 41 protein non-coding genes) and 254 drugs of CAC in mammals by manual review of 602 published papers. Meanwhile, to evaluate the prognostic value of interest CAC protein-encoding gene, dbCAC reprocessed 160 gene expression datasets from GEO (Gene Expression Omnibus), ICGC (International Cancer Genome Consortium), TCGA (The Cancer Genome Atlas) database and published literature involving a total of 22985 cancer patients with clinical survival information. dbCAC is the first database for CAC that not only provides a user-friendly interface for searching, browsing and analyzing but also allows flexible data downloading and user data submitting.

Statistic

Number of CAC related genes: 293
Number of drugs: 254
Number of publications: 602
Number of gene expression datasets: 160
Number of cancer patients: 22985

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