Welcome to OStme !
Tumor microenvironment (TME) is emerging as critical interface that play important roles in the development and progression of cancer. However, the association between TME and prognosis in diverse solid tumors in a systematic manner are still lacking. OStme (Online consensus Survival analysis webserver for Tumor MicroEnvironment components of pan-cancers) is capable to measure the association between cancer prognosis and 64 types of tumor infiltrating cells (TIC), and to investigate the fraction variations of TIC across different stages/grades or variations regarding therapies. OStme encompasses 141 expression datasets from TCGA, GEO, CGGA databases and literatures, provides 12 types of survival terms for 23,917 clinical samples across 31 distinct malignancies, offers four analysis modules for patient survival analysis, differential analysis per clinical characteristics, TME fraction estimation, the correlation between gene expression and TIC abundance of pan-cancers.
OStme
ACC: Adrenocortical carcinoma. BLCA: Bladder Urothelial Carcinoma. BRCA: Breast invasive carcinoma. CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma. CHOL: Cholangio carcinoma. COAD: Colon adenocarcinoma. DLBCL: Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. ESCA: Esophageal carcinoma. GBM: Glioblastoma multiforme. HNSC: Head and Neck squamous cell carcinoma. KICH: Kidney Chromophobe. KIRC: Kidney renal clear cell carcinoma. KIRP: Kidney renal papillary cell carcinoma. LGG: Brain Lower Grade Glioma. LIHC: Liver hepatocellular carcinoma. LUAD: Lung adenocarcinoma. LUSC: Lung squamous cell carcinoma. MESO: Mesothelioma. OV: Ovarian serous cystadenocarcinoma. PAAD: Pancreatic adenocarcinoma. PCPG: Pheochromocytoma and Paraganglioma. PRAD: Prostate adenocarcinoma. READ: Rectum adenocarcinoma. SARC: Sarcoma. SKCM: Skin Cutaneous Melanoma. STAD: Stomach adenocarcinoma. TGCT: Testicular Germ Cell Tumors. THCA: Thyroid carcinoma. THYM: Thymoma. UCEC: Uterine Corpus Endometrial Carcinoma. UCS: Uterine Carcinosarcoma. UVM: Uveal Melanoma.
Statistics:
Cancer types: 31
Tumor infiltrating cell types: 64
Survival terms: 12
Tumor samples: 23917
Normal samples: 5205
Expression datasets: 141
Please feel free to contact us if you have any questions on OStme using or need any help to curate your own data for cancer tumor microenvironment studies. Qiang Wang, Research Bioinformatics Scientist, qiangwang@henu.edu.cn; Xiangqian Guo, Professor, xguo@henu.edu.cn
Copyright © 2020 Biomedical Informatics Institute
