Welcome to dbTAMP !

Macrophages in the TME (tumor microenvironment), namely tumor-associated macrophages (TAMs), has certain plasticity, and can be polarized into M1 type (inhibiting tumor progression), and an alternatively activated M2 phenotype (enhancing tumor malignancy in the majority of cases). M2 type TAMs are recruited by cytokines secreted by tumor cells to enhance tumor growth and metastasis. Here, we developed a database of dbTAMP (a comprehensive database of Tumor Associated Macrophage Polarization), which covers 668 genes (527 protein-encoding genes and 141 protein non-coding genes) and 150 drugs related with TAMs derived from 13857 published articles in PubMed. It provides not only a user-friendly interface for searching, browsing but also four analysis modules for survival analysis, differential analysis, infiltration estimation and infiltration association.