Introduction

dbSCI is a database for inhibitors of SARS-CoV-2 which were from in vitro and in vivo studies, clinical trials or computational studies from published papers. dbSCI contains features for the inhibitors of SARS-CoV-2, including pharmacological information of in vitro studies (IC50, EC50, CC50), the effectiveness of drugs in clinical trials (positive or negative), and the imperative information of drugs from bioinformatics studies (IUPAC name, CID and SMILES ) and other detailed information.

Search

Users can input the interested target proteins and/or drug names to retrieve the data.

1. Search by protein name.

If you want to query a protein or peptide by name, e.g. NSP3, you can input " NSP3 " and press " Search " button. The results list all potential entries related to your inputted " NSP3 ". The related information about the inhibitors of the inputted proteins are returned.

2. Search by drug name.

Example: If you want to query a potential drug, which may inhibit the SARS-CoV-2, e.g. Lopinavir, you should input the drug name " Lopinavir " in the box. The results list all potential entries related to your inputted " Lopinavir ". The related information about the drug are shown.

Browse

dbSCI includes 3 parts such as " Cell experiments ", " Clinical trials ", " Virtual drug screening ". You can browse any interesting parts, e.g. Cell experiments. Then, click on " Cell experiments " and all entries related to your choose will be shown.

Download and Submit

All the data in the dbSCI are freely to be downloaded. dbSCI has provided "Download" and "Submit" interfaces for users download all data about potential inhibitors of SARS-CoV-2 information in a tab-separated file and submit new potential inhibitors of SARS-CoV-2 datas.